학력
- 2011년 성균관대학교 학사
- 2012년 Georgetown University 석사
- 2018년 Purdue University 박사
경력
- 2018년 – 2020년 미국 University of Pennsylvania, Center for Cellular Immunotherapies, 박사후 연구원
- 2021년 – 현재한양대학교 약학대학 조교수
수상경력
Lymphoma Research Foundation Postdoctoral Fellowship Grant (2020 – 2022) :
학회활동
- 대한약학회 회원
- 대한면역학회 회원
- American Association for Cancer Research (AACR) 회원
- The New York Academy of Sciences 회원
- Society for Immunotherapy of Cancer (SITC) 회원
- American Society for Gene and Cell Therapy (ASGCT) 회원
- American Society of Hematology 회원
논문
Publications
Nathan Singh*, Noelle V. Frey*, Boris Engels*, David M. Barrett, Olga Shestova, Pranali Ravikumar, Katherine D. Cummins, Yong Gu Lee, Raymone Pajarillo, Inkook Chun, Amy Shyu, Steven L. Highfill, Andrew Price, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xueqing Maggie Lu, David A. Christian, Jessica Perazzelli, Simon F. Lacey, Nathan H. Roy, Janis K. Burkhardt, Florent Colomb, Mohammad Damra, Mohamed Abdel-Mohsen, Ting Liu, Dongfang Liu, Daron M. Standley, Regina M. Young, Jennifer L. Brogdon, Stephan A. Grupp, Carl H. June, Shannon L. Maude*, Saar Gill* and Marco Ruella*, Antigen-independent activation enhances the efficacy of 41BB co-stimulated CD22 CAR T cells, Nature Medicine. (2021, In press)
Puneeth Guruprasad, Yong Gu Lee, Ki Hyun Kim, Marco Ruella, The current landscape of single-cell transcriptomics for cancer immunotherapy, J Exp Med. (2021) 218 (1):e20201574
Nathan Singh*, Yong Gu Lee*, Olga Shestova, Pranali Ravikumar, Katharina E hayer, Seok Jae Hong, Xueqing Maggie Lu, Raymone Pajarillo, Sangya Agarwal, Shunichiro Kuramitsu, Elena L. Berger, Ophir Shalem, Matthew D Weizman, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp, Carl H. June, Saar Gill and Marco Ruella. Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction. Cancer Discovery. April 1 2020 10 (4) 552-567; DOI:10.1158/2159-8290.CD-0813. Selected as cover page for the issue. *Co-first author.
Yong Gu Lee, Haiyan Chu, Yingjuan Lu, Christopher P. Leamon, Madduri Srinivasarao, Karson S. Putt and Philip S. Low, Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters. Nature communications. 2019. 10(1): 2681.
Yong Gu Lee, Isaac Marks, Madduri Srinivasarao, Ananda Kandaluru, Mahalingam S., Haiyan Chu, and Philip S. Low. Use of a single CAR T cell and several bispecific adapters facilitates eradication of multiple antigenically different solid tumors. Cancer research 79.2 (2019): 387-396.
Marcel Oliver Schmidt, Khalid Ammar Garman, Yong Gu Lee, Chong Zuo, Patrick James Beck, Mingjun Tan, Juan Antonio Aguilar-Pimentel, Markus Ollert, Carsten Schmidt-Weber, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, German Mouse Clinic Consortium, Elena Tassi, Anna Tate Riegel, and Anton Wellstein. The role of fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation. Journal of Investigative Dermatology. 2018. Jan;138(1):179-188
Donghoon Yoon, David V. Okhotin, Bumjun Kim, Yulia Okhotina, Daniel J. Okhotin, Galina Y. Miasnikova, Adelina I. Sergueeva, Lydia A. Polyakova, Alexei Maslow, Yong Gu Lee, Gregg L. Semenza, Josef T. Prchal, and Victor R. Gordeuk. Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α. Journal of Molecular Medicine. 2010. 88(5): 523- 530.
Patents
Philip S. Low, Haiyan Chu, Yong Gu Lee. Chimeric antigen receptor-expressing t
cells as anti-cancer therapeutics. 2019. EP2934532B1.
Marco Ruella, Yong Gu Lee. METHODS AND COMPOSITIONS COMPRISING
CART AND A SMAC MIMETIC. 2019. PCT/US2019/019158.
Philip S. Low, Haiyan Chu, Yong Gu Lee, Yingjuan J Lu, Christopher Paul Leamon, Leroy w. Wheeler II. 2018. Compositions and Methods for CAR T cell therapy. PCT/US2018/20095.
Philip S. Low, Haiyan Chu, Yong Gu Lee. Methods and Compositions for CAR T cell therapy. 2017. PCT/US2017/026618