교수소개

남태규 부교수

약학과
연구분야 : 약품제조화학/생유기화학

연락처 : 031-400-5807

■ 학력 
- 학사: 서울대학교 제약학과 (1993)
- 석사: 서울대학교 약학과 (1995) 지도교수: 주상섭, Ph.D.
- 박사: Vanderbilt University (2006) 지도교수 Ned A. Porter, Ph.D.
 
■ 연구경력
- 1995-2000: LG 생명과학연구소 (대전), 연구원
- 2006-2009: The Scripps Research Institute, La Jolla, CA, USA, 박사후 연수과정, 지도교수: Peter G. Schultz, Ph.D.
- 2009-2011: 경기과학기술진흥원, 경기바이오센터 (수원), 수석연구원
- 2011-현재: 한양대학교 약학과, 조교수
 
남태규 교수는 서울대학교 약학대학에서 학사, 석사를 마치고, LG생명과학연구소에서 연구원으로서 근무하였다. 이 시기에 국산신약으로서 최초로 미국 FDA의 승인을 받은 퀴놀론계 항생제인 Factive 의 개발에 참여하였다. 이후, 도미하여 University of North Carolina-Chapel Hill의 department of Environmental Sciences and Engineering 에서 박사 학위 과정을 시작하여, 이듬해 Vanderbilt University 화학과로 옮긴후 Ned A. Porter 교수의 지도아래 항산화제와 지질과산화 (lipid peroxidation)의 생유기화학(bioorganic chemistry)에 대하여 박사학위를 취득하였다. 
이후, 미국 San Diego 소재 The Scripps Research Institute 화학과의 Peter G. Schultz 교수 지도 아래 Genomics Institute of the Novartis Research Foundation (GNF)연구진과 함께 High Throughput Screening을 이용한 functional genomics 프로젝트를 수행하였다. 귀국후 2년동안 경기바이오센터에서 국내 최대 규모의 화합물 은행과 HTS 시스템을 구축하고 이를 이용한 신약개발 프로젝트를 수행하였며, 2011부터 한양대학교 약학대학에서 조교수로 근무하고 있다. 


■ Education
Ph. D. Vanderbilt University (2006), Advisor: Ned A. Porter, Ph.D.
M. S. Seoul National University (1995), Advisor: Sang-sup Jew, Ph.D.
B. S. Seoul National University (SNU, 1993)

■ Research Experience
2011-present, Department of Pharmacy, Hanyang University, Ansan, Korea, 
2009-2011, Gyeonggi Bio-Center, Gyeonggi Institute of Science and Technology Promotion (GSTEP), Suwon, Korea
2006-2009, The Scripps Research Institute (TSRI), La Jolla, CA, USA, Advisor: Peter G. Schultz, Ph.D.
1995-2000, LG Life Sciences (LGLS), Dae-jon, Korea 

Tae-gyu (Tag) Nam did his undergraduate and M. S. work at the College of Pharmacy, Seoul National University. Then, he worked in LG Life Sciences where he was involved in the development of Factive, the first Korean-made drug approved by US FDA. He has started his Ph.D. study at department of Environmental Sciences and Engineering in University of North Carolina-Chapel Hill in 2000. He continued his Ph.D. work at the department of Chemistry at Vanderbilt University with professor Ned A. Porter on the bioorganic chemistry of antioxidants.
Next, he joined Peter G. Schultz group in The Scripps Research Institute for postdoctoral studies where he carried out a couple of functional genomics projects by using High Throughput Screening (HTS) technology in the collaboration with scientists from Genomics Institute of the Novartis Research Foundation (GNF). In 2011, after two year works on HTS-based drug discovery projects at Gyeonggi Bio-Center (GGBC), he joined the faculty of Hanyang University where he is currently an assistant professor of Pharmacy. 

■ Publication

Choi, Y.; Nam, T.-G.* "Chemical Biology in Stem Cell Research" Archives of Pharmacal Research, 2012, 35(2), 281-297.

Meister, S.; Plouffe, D. M.; Kuhen, K.; Bonamy, G. MC.; Wu, T.; Barnes, S. W.; Bopp, S. E.; Borboa, R.; Bright, A. T.; Che, J.; Cohen, S.; Dharia, N. V.; Gagaring, K.; Gettayacamin, M.; Gordon, P.; Groessl, T.; Kato, N.; Lee, M. CS.; McNamara, C.; Fidock, D. A.; Nagle, A.; Nam, T. –G.; Richmond, W.; Roland, J.; Rottmann, M.; Zhou, B.; Froissard, P.; Glynne, R. J.; Mazier, D.; Sattabongkot, J.; Schultz, P. G.; Tuntland, T.; Walker, J. R.; Zhou, Y.; Chatterjee, A.; Diagana, T. T.; Winzeler, E. A.* "Imaging of Plasmodium Liver Stages to Drive Next Generation Antimalarial Drug Discovery" Science, 2011, 334(6061), 1372-1377.

Nam, T.-G.; McNamara, C.; Bopp, S.; Dharia, N. V.; Meister, S.; Plouffe, D. M.; Kato, N.; McCormack, S.; Bursulaya, B.; Ke, H.; Vaidya, A. B.; Schultz, P. G.*; Winzeler, E. A.* "A chemical genomic analysis of decoquinate, a P. falciparum cytochrome B inhibitor" ACS Chemical Biology, 2011, 6(11), 1214-1222.

Nam, T.-G.; Ku, J.-M.; Rector, C. L.; Choi, H.; Porter, N. A.*, Jeong, B. S.* "Pyridoxine-Derived Bicyclic Aminopyridinol Antioxidants; Synthesis and Their Antioxidant Activities" Organic & Biomolecular Chemistry, 2011, 9, 8475-8482.

Nam, T.-G.; Lee, J.; Walker, J.; Brinker, A.; Cho, C. Y.; Schultz, P. G.* "Identification and Characterization of Small Molecule Inducers of Fetal Hemoglobin“ ChemMedChem, 2011, 6(5), 777-780.

Nam, T.-G.* "Lipid Peroxidation and Its Toxicological Implications“ Toxicological Research, 2011, 27(1), 1-6.

Nam, T.-G.; Koo, J. M.; Park, H.-G.; Porter, N. A.*; Jeong, B. S.* "New Synthetic Route to N-Tocopherol Derivatives: Synthesis of Pyrrolopyridinol Analogue of alpha-Tocopherol from Pyridoxine“ Organic & Biomolecular Chemistry, 2011, 9, 1749-1755.

Serwa, R.‡; Nam, T.-G. ‡; Valgimigli, L.; Culbertson, S.; Rector, C. L.; Jeong, B. -S.*; Pratt, D. A.; Porter, N. A.* "Preparation and Investigation of Vitamin B6 Derived Aminopyridinol Antioxidant" ‡equally contributed as co-first author, Chemistry-A European Journal, 2010, 16(47), 14106-14114.

Omata, Y.; Saito, Y.; Yoshida, Y.; Jeong, B.-S.; Serwa, R.; Nam, T.-G.; Porter, N. A.; Niki, E.* "Action of 6-Amino-3-Pyridinols Against Free Radicals and Oxidative Stress in Solution, Plasma, and Cultured Cells“ Free Radical Biology & Medicine, 2010, 48(10),1358-1365.

Nam, T.-G.; Nara, S. J.; Zagol-Ikapitte, I.; Cooper, T.; Valgimigli, L.; Oates, J. A.; Porter, N. A.; Boutaud, O.*; Pratt, D. A.* "Pyridine and Pyrimidine Analogs of Acetaminophen as Inhibitors of Lipid Peroxidation and Cyclooxygenase and Lipoxygenase Catalysis“ Organic &. Biomolecular Chemistry, 2009, 7(24), 5103- 5112, selected as Hot Article of the Issue.

Lee, J.; Hong, J.; Nam, T.-G.; Peters, E. C.; Orth, A. P.; Geierstanger, B. H.; Goldfinger, L. E.; Ginsberg, M. H.; Cho, C. Y.*; Schultz, P. G.* "A Small Molecule Inhibitor of alpha4 Integrin-Dependent Cell Migration“ Bioorganic & Medicinal Chemistry, 2009, 17(3), 977-980, Dedicated to the special issue for Professor Jonathan Ellman.

Plouffe, D.; Brinker, A.; McNamara, C.; Henson, K.; Kato, N.; Kuhen, K.; Nagle, A.; Adrian, F.; Matzen, J.; Anderson, P.; Nam, T.-G.; Gray, N. S.; Chatterjee, A.; Janes, J.; Yan, S. F.; Trager, R.; Caldwell, J. S.; Schultz, P. G.; Zhou, Y.; Winzeler, E. A.* "In Silico Activity Profiling Reveals The Mechanism of Action of Antimalarials Discovered In a High-Throughput Screen" Proceedings of National Academy of Sciences USA, 2008, 105(26), 9059-9064.

Kang-Sickel, J. C.; Fox, D. D.; Nam, T.-G.; Jayaraj, K.; Ball, L. M.; French, J. E.; Klapper, D. G.; Gold, A.*; Nylander-French, L.* "S-arylcysteine Adducts in Keratin as Biomarkers of Dermal Exposure to Aromatic Hydrocarbons" Chemical Research in Toxicology, 2008, 21(4), 852-858.

Nam, T.-G.; Rector, C. L.; Kim, H. Y.; Sonnen A. F.–P.; Meyer, R.; Nau, W. M.; Atkinson, J.; Rintoul, J.; Pratt, D. A.*; Porter, N. A.* "Tetrahydro-1,8-Naphthyridinol Analogues of α-Tocopherol as Antioxidants in Lipid Membranes and Low Density Lipoproteins“ Journal of the American Chemical Society, 2007, 129, 10211-10219.

Nam, T.-G.; Wijtmans, M.; Pratt, D. A.*; Porter, N. A.* "Regioselective addition of n-alkyllithiums to alpah,alpha’-disubstituted-1,8-naphthyridines: Synthesis of 6-amino-3-pyridinol analogs of alpha-tocopherol" Synthesis, 2005, 9, 1397-1404, Dedicated to the special issue for Professor Bernd Giese.

Gold, A.*; Nam, T.-G.; Jayaraj, K.; Sangaiah, R.; Kalpper, D. G.; Ball, L. M.; French, J. E.; Nylander-French, L A. "Synthesis of S-Aryl-DL-Cysteines and Incorporation into Keratin Sequences" Organic Preparations & Procedures International, 2003, 35(4), 375-382.

Nam, T.-G.; Sangaiah, R.; Gold, A.*; Lacks, G, D.; French, J. E.; Nylander-French, L. A. "Synthesis of FMOC-protected S-Arylcysteines and Modified Keratin Sequence Peptides as Specific Epitopes as Immunogens" Polycyclic Aromatic Compounds, 2002, 22(3-4), 239-248